Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 104619-51-4, name is Di(1H-imidazol-1-yl)methanimine, A new synthetic method of this compound is introduced below., Formula: C7H7N5
A solution of Intermediate 32 (260 mg, 0.470 mmol) in DMSO (2 mL) was treated with di(lH-imidazol-l-yl)methanimine (151 mg, 0.939 mmol) and the mixture was stirred until all of the latter had dissolved. Stirring was then continued for a further 3 h and the mixture was allowed to stand at RT overnight. The mixture was diluted with ethyl acetate and the solution was washed with water. The aqueous was further extracted with ethyl acetate and the combined organics were washed with brine, dried (MgS04) and evaporated. The product was purified on a 5 g Si cartridge eluting with 1 : 1 ethyl acetate in DCM to give the desired product (180 mg). LCMS (Method 4): Rt = 1.55 min, m/z 579.5 [M+H]+
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; CHIESI FARMACEUTICI S.P.A.; ACCETTA, Alessandro; RANCATI, Fabio; CLARK, David Edward; EDWARDS, Christine; (113 pag.)WO2019/238628; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem