These common heterocyclic compound, 106429-57-6, name is Methyl 2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 106429-57-6
2-oxo- 2,3-dihydro-1 /-/-benzoimidazole-5-carboxylic acid methyl ester (3.00 g, 15.6 mmol) and phosphorus oxychloride (30 ml_) were combined and heated to 100 0C for 48 h. The mixture was cooled to 23 0C and concentrated under reduced pressure. The residue was cooled to 0 0C, and cold, saturated aqueous NaHCO3 (60 ml_) was added cautiously. After stirring at 23 0C for 15 min, the mixture was sonicated and the resulting residue was filtered to yield the titled compound (3.13 g, 95%), which was used in the next step without further purification. MS (ESI/CI): mass calcd. for C9H7CIN2O2, 210.02; m/z found, 211.0 [M+H]+.
The synthetic route of Methyl 2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; WO2009/134750; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem