139481-44-0, name is Methyl 1-((2′-cyano-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 139481-44-0
Raw material (compound 2A) 20 g, in the reaction bottle, adding ethanol to 200 ml, triethylamine 5 g, 50% aqueous hydroxylamine solution 37 g, reaction 24h, the cooling crystallization, the white solid obtained 13.6 g (63.0%). HPLC detection reaction in the reaction solution at the end of the major amide impurity (compound 6A): product is 7.15% : 92.84% (that is, the impurity and the product of the ratio of 1 : 12.9), see Figure 2.
Statistics shows that 139481-44-0 is playing an increasingly important role. we look forward to future research findings about Methyl 1-((2′-cyano-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate.
Reference:
Patent; Shanghai Institute of Pharmaceutical Industry; China State Institute of Pharmaceutical Industry; Wang, Xiaomei; Sui, Qiang; Tang, Chao; Liu, Shuai; Ouyang, Qunxiang; Shi, Huilin; (17 pag.)CN103664792; (2016); B;,
Imidazole – Wikipedia,
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