Research on new synthetic routes about 2-(1H-Imidazol-1-yl)acetic acid

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 22884-10-2, name is 2-(1H-Imidazol-1-yl)acetic acid, A new synthetic method of this compound is introduced below., Safety of 2-(1H-Imidazol-1-yl)acetic acid

Step (2): Compound 76 + Compound 77 ? Compound 78; To Compound 76 (126 mg, 1.0 mmol) was added dichloromethane (4 ml), Compound 77 (365 mg, 1.00 mmol), and WSCD·HCl (249 mg, 1.30 mmol), followed by stirring at 0C for 1 hour and then at room temperature for 1 hour. Dimethylformamide (2 ml) was added, subsequently stirring for 1 hour, and then concentrated in vacuo to evaporate dichloromethane. Dimethylformamide (2 ml) was added, and then allowed to stand for 3 days. Dichloromethane and water were then added. The organic layer was washed with water, washed with saturated brine, dried over magnesium sulfate, and then filtrated to yield Compound 78 (390 mg, 58% yield, 70% potency).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shionogi&Co., Ltd.; EP2341053; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem