These common heterocyclic compound, 7098-07-9, name is 1-Ethyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1-Ethyl-1H-imidazole
To the dry 100 mL three-necked flask was added 6.3 g (10 mmol) of M2 ‘, 0.96 g (10 mmol) of 1-ethyl terephthalate, 50 mL of acetonitrile, reacted at room temperature for 4 days and TLC was used to monitor the reaction end. Washed with petroleum ether (100 mL x 3) to give a viscous liquid which was washed with ether (100 mL x 3), dried in vacuo for 24 h, To give 7.2 g of the title compound (B5) as a brown oily liquid in a yield of 99percent.
The synthetic route of 1-Ethyl-1H-imidazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Central China Normal University; Zhang Aidong; Zhang Tiejiang; Duan Jiang; Tu Haiyang; (22 pag.)CN107188869; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem