Electric Literature of 51605-32-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 51605-32-4 as follows.
Hydrolysis of ethyl-4-methyl-1H-imidazole carboxylate(7, 3.0 g, 19.5 mmol) was carried out in a basic medium offreshly prepared 2 M NaOH solution for 3 h. Neutralizationwith glacial acetic acid was performed after the completionof the reaction. The aqueous solvent was evaporated underreduced pressure and 10 mL of absolute ethanol was used tore-dissolve the white solid product. The reaction mixture wasfiltered off and the precipitate was dissolved several timeswith absolute ethanol and co-evaporation was performed toremove water traces. 4-Methyl-1H-imidazole-5-carboxylic acid(8) was obtained as a white solid with a yield of 87.8%.
According to the analysis of related databases, 51605-32-4, the application of this compound in the production field has become more and more popular.
Reference:
Article; Jasim, Suhair H.; Sheikha, Ghassan M. Abu; Abuzaid, Haneen M.; Al-Qirim, Tariq M.; Shattat, Ghassan F.; Sabbah, Dima A.; Ala, Samah A.; Aboumair, Mustafa S.; Sweidan, Kamal A.; Bkhaitan, Majdi M.; Chemical and Pharmaceutical Bulletin; vol. 66; 10; (2018); p. 953 – 958;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem