Adding a certain compound to certain chemical reactions, such as: 60-56-0, name is 1-Methyl-1H-imidazole-2(3H)-thione, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 60-56-0, SDS of cas: 60-56-0
General procedure: To a slurry of the substituted imidazole-2-thione or pyrimidine-2-thiol (1.0 mmol) and sodium methoxide (2.2 mmol) in methanol (20 mL) was added a solution of substituted 2-(chloromethyl)-pyridine (1.0 mmol) in methanol (10 mL). After the mixture was refluxed with stirring for 4-6 h, the solvent was removed in vacuo and the residue was washed with water to remove the salt, and then extracted with dichloromethane (3 9 10 mL) at room temperature. The solid product was directly obtained by the removal of solvent and further dried at 45 C overnight. The purity of the product was tested by HPLC and characterization of the product was confirmed by IR, 1H NMR, and mass spectroscopies. Data 3-Methyl-[4-(2,2,2-Trifluoroethoxy)-2-Pyridinyl]-Methylthio-1-Methyl-Imidazole (3a) White solid. Yield: 84.5 %. IR (cm-1): 832.7 (-CH2-S-). 1H NMR (CDCl3) delta (ppm): 2.18 (s, 3H, -CH3 in py), 3.23 (s, 3H, -CH3 in imidazole), 4.42 (q, J = 6.0 Hz, 2H,-OCH2CF3), 4.56 (s, 2H, -CH2S-), 6.62 (d, J = 5.6 Hz,1H, H in py), 6.81 (s, 1H, H in imidazole), 6.92 (s, 1H,H in imidazole), 8.30 (d, J = 5.6 Hz, 1H, H in py). MS (EI): m/z calcd. C13H14N3OF3S (M+) 317.3311, found 317.3336.
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Reference:
Article; Ma, Sen; Jia, Ai-Quan; Fan, Fang-Fang; Shi, Hua-Tian; Zhang, Qian-Feng; Journal of Chemical Crystallography; vol. 46; 3; (2016); p. 137 – 143;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem