75370-65-9, name is 4-Amino-1H-benzo[d]imidazol-2(3H)-one, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 75370-65-9
Amine 2bf (1.1 g, 6.7 mmol) was dissolved in 40ml of AcOEt and at0C triphosgene (1.93 g, 6.7 mmol) was added to the solution. The mixture was warmed at 80C for 4 hours then evaporated and the residue was dissolved in 15ml of DMF. The solution of the isocyanate was added dropwise to a solution in DMF (10 ml) of compound la (1 g, 6.7 mmol) and the mixture was warmed at 80C for 8 hours. (TLC AcOEt 9.5 / MeOH 0.5). The solvent was evaporated and the crude was dissolved in AcOEt (50 ml) and washed with water (1 X 30 ml) and brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by chromatographic column gave 450 mg of a pale yellow solid. Yield = 19% ‘HNMR (DMSO, 200 MHz) delta 2.26 (3H, s), 2.59 (6H, m), 4.33 (2H, d, J = 5.6 Hz), 6.60 (2H, m), 6.87 (4H, m), 7.18 (1H, d, J = 7.6 Hz), 8.28 (1H, s), 9.96 (1H, bs), 10.60 (1H, bs); [M+1] 339.56 (C18H21N5O2 requires 339.39).
The synthetic route of 75370-65-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHARMESTE S.R.L.; NAPOLETANO, Mauro; TREVISANI, Marcello; PAVANI, Maria Giovanna; FRUTTAROLO, Francesca; WO2011/120604; (2011); A1;,
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