These common heterocyclic compound, 288-32-4, name is 1H-Imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 288-32-4
To a slightly yellow homogeneous solution of imidazole (5.000 g; 73.444 mmol) in dioxane (135 ml) and distilled water (135 ml) was added successively, at rt (in one portion), sodium carbonate (35.029 g; 330.500 mmol), and iodine (61.515 g; 242.366 mmol). The resulting brown heterogeneous reaction mixture was further stirred at rt, under nitrogen, for 24h. EA (250 ml) was then added followed by an aq. solution of sodium thiosulfate (22.50 g Na2S2O3 in 150 ml of water). The yellow homogeneous organic layer was then dried over anh. MgSO4, filtered, and concentrated to dryness under reduced pressure to give the crude product 2, 4, 5-triiodo-1 /-/-imidazole as a yellow solid which was further dried under HV (32.700 g; 100%). LC-MS: tR = 0.78 min.; [M+H]+ = 447.03 g/mol.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 288-32-4.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2008/78291; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem