Reference of 17289-26-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17289-26-8, name is 1-Methyl-1H-imidazole-4-carbaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a 0.2 M solution of intermediate (l-36a) in THF was added 1.1 eq 1 -methyl- 1 H-imidazole-4-carbaldehyde (Ryan Scientific, Inc., Mt. Pleasant, SC), and this solution was then cooled to 0 C. To this solution was added 0.5 equivalents of potassium t- butoxide as a 1 M solution in THF, and the reaction was allowed to slowly warm to RT. After 18h the solution was acidified with 1 N HCI, brine was added, and extracting three times with ethyl acetate. The resulting organic layers were then combined, dried over sodium sulfate and concentrated to afford crude (l-36b). This material was taken forward crude.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-imidazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PFIZER INC.; BENBOW, John William; LOU, Jihong; PFEFFERKORN, Jeffrey Allen; TU, Meihua Mike; WO2010/29461; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem