Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1467-16-9, name is 1H-Imidazole hydrochloride, A new synthetic method of this compound is introduced below., Recommanded Product: 1467-16-9
A mixture of lithium(1+) ion 3-amino-7-chloro-5/-/-pyrrolo[2,3- 5]pyrazine-2-carboxylate, Intermediate 12 (90 mg, 0.45 mmol), CDI (1 10 mg, 0.67 mmol) and 1 /-/-imidazole hydrochloride (1 : 1) (56 mg, 0.53 mmol) in DMF (2 ml) was stirred at RT for 1 h. Additional CDI (50 mg, 0.31 mmol) was added and the reaction was allowed to continue for a further 1 h. The reaction mixture was diluted with water (4 ml) then filtered. The solid was washed with water then dried under vacuum to afford the product as a yellow solid (83 mg, 75%). 1 H NMR (500 MHz, DMSO-cfe) delta 1 1.37 (s, 1 H), 8.84 (s, 1 H), 8.00 (t, J = 1.4 Hz, 1 H), 7.45 (s, 2H), 7.41 – 7.37 (m, 1 H), 7.12 – 7.08 (m, 1 H), 2.22 (d, J = 1.1 Hz, 3H). LC/MS (System A): m/z (ESI+) = 243 [MH+], Rt = 0.78 min, UV purity = 98%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ENTERPRISE THERAPEUTICS LIMITED; MCCARTHY, Clive; HARGRAVE, Jonathan, David; HAY, Duncan, Alexander; SCHOFIELD, Thomas, Beauregard; WENT, Naomi; (261 pag.)WO2018/96325; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem