1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 2-(1-Trityl-4-imidazolyl)benzaldehyde
In the atmosphere of nitrogen and ice bath conditions,Will be 60% sodium hydride (38 mg, 0.97 mmol, 1.0 equiv)Dissolved in 15 ml of tetrahydrofuran,(2-(7-Fluorobenzofuran-5-yl)-2-oxoethyl)phosphoric acid dimethyl ester (0207-14) (278 mg, 0.97 mmol, 1.0 equiv) was slowly addedTetrahydrofuran solution (15 ml).After stirring the mixture for 15 minutes,2-(1-trityl-1H-imidazol-4-yl)benzaldehyde (0105-1) (402 mg, 0.97 mmol, 1.0 equiv)A solution of tetrahydrofuran (20 ml) was added dropwise thereto.The mixture was stirred at ice bath for 0.5 hours.The reaction was warmed to room temperature and stirred overnight. After the reaction is completed, quench with saturated aqueous ammonium chloride, dichlorineMethane was extracted and the organic phase was washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a yellow oil. The result isPurification by silica gel column chromatography (eluent: ethyl acetate/petroleum ether = 1/2) yields the desired product 1-(7-fluorobenzofuran-5-Radyl)-3-(2-(1-trityl-1H-imidazol-4-yl)phenyl)prop-2-en-1-one (252 mg, yield: 45.2%) wasYellow oil.
The synthetic route of 1402838-08-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
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