In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 52099-72-6 as follows. 52099-72-6
1-Isopropenyl-2-benzimidazolone (4.0 g, 0.023 mol), Intermediate I (9.8 g, 0.03 mol), 45% NaOH (12¡¤5 g, 0¡¤14 mol), was added to a 250 ml reaction flask. 25 ml of propanol and 110 ml of water were heated to 75 degrees and stirred for 2 hours. The reaction was completed, concentrated hydrochloric acid was added to adjust PHI, stirring was continued for 1 h, and the solid obtained by filtration was cooled.Adding to DCM and water, adjusting the pH to alkaline, separating the organic layer, drying and concentrating, and concentrating the obtained product by recrystallization from acetone to obtain the finished product of Flibanserin.
According to the analysis of related databases, 52099-72-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Guangzhou Langsheng Pharmaceutical Co., Ltd.; Li Zhimin; Chen Yuhua; Zhao Yujiao; Chen Weiqiang; Zhao Zhirong; Lu Zhijun; (7 pag.)CN109384680; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem