41716-18-1, A common compound: 41716-18-1, name is 1-Methyl-1H-imidazole-4-carboxylic acid, belongs to imidazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
Example 141-Methyl-N-[3-methyl-5-(trifluoromethoxy)benzyl]-N-(tetrahydro-2H-thiopyran-4-yl)-1H-imidiazole-4-carboxamideA mixture of N-[3-methyl-5-(trifluoromethoxy)benzyl]tetrahydro-2H-thiopyran-4-amine (830 mg), 1-methyl-1H-imidazole-4-carboxylic acid (380 mg), EDC.HCl (860 mg), HOBt (460 mg), dimethylformamide (20 mL) and triethylamine (0.94 mL) was stirred overnight at room temperature.The solvents were distilled off under reduced pressure and extraction was conducted with ethyl acetate; the organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate and saturated saline and dried over anhydrous magnesium sulfate.After filtering off the desiccant, the solvent was concenrated.The residue was purified by column chromatography (NH silica gel cartridge; hexane/ethyl acetate=90:10 to 10:90) to give the titled compound (810 mg).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-imidazole-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; US2012/10414; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem