A common heterocyclic compound, 10111-08-7, name is Imidazole-2-carboxaldehyde, molecular formula is C4H4N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 10111-08-7.
Example 61;3H-Imidazole-2,4-dicarboxylic acid 2-amide 4-{ [2-(4,4-dimethyl-cyclohex-l-enyl)- phenyl] -amide}; a) 1 -(2-Trimethylsilanyl-ethoxymethyl)- lH-imidazole-2-carbaldehyde; A mixture of lH-imidazole-2-carbaldehyde (1.1 g, 11 mmol), potassium carbonate (3.0 g, 23 mmol), and SEM-Cl (2.4 mL, 14 mmol) in 10 mL of acetone was heated to 60 0C for 8 h. The mixture was diluted with EtOAc (100 mL) and washed with NaHCO3 (2 x 100 mL) and brine (100 mL) and the organic layer dried (Na2SO4) and concentrated. The title compound was purified by elution from a 20-g SPE column with 50 % EtOAc to give 1.5 g (58 %) of a colorless oil. 1H-NMR (CDCl3, 400 MHz): delta 9.82 (s, IH), 7.38 (d, J = 1.0 Hz, IH), 7.34 (d, J = 1.0 Hz, IH), 5.78 (s, 2H), 3.55 (m, 2H), 0.94 (m, 2H), -0.02 (s, 9H).
The synthetic route of Imidazole-2-carboxaldehyde has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2007/123516; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem