Electric Literature of 288-32-4,Some common heterocyclic compound, 288-32-4, name is 1H-Imidazole, molecular formula is C3H4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(1) Preparation of nitric-sulfuric mixed acid: at 10 C, sequentially, in a beaker 54mL of fuming sulfuric acid and slowly dropping 12.8mL of fuming nitric acid and during adding process of fuming nitric acid attention to keep stirring; (2) At room temperature, 22 mL of fuming sulfuric acid and 13.6 g (0.2 mol) of imidazole were added slowly to a three-necked flask, the reaction continuously stirred for 30 min, and the mixture was thoroughly mixed. The temperatures was then set to 65 C and after reaching to a corresponding temperature add the whole nitric-sulfuric mixed acid prepared above, and reaction was carried out for 1h. After the end of the reaction, slowly poured into 550g ice water, stirring it until it is melt, and then heated to 120 C and reacted for 1h. then cooling, suction and drying was carried out to obtain 4-NI;
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Imidazole, its application will become more common.
Reference:
Patent; North University of China; Liu Yucun; Luo Jin; Liu Yan; Chai Tao; (14 pag.)CN106831598; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem