In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2302-25-2 as follows. name: 4-Bromo-1H-imidazole
In nitrogen atmosphere to 5.0g (34mmol) 4-bromo-1H-imidazole, 7.14g (35mmol) Iodobenzene, 0.27g (4.25mmol) copper, 3.5g (25.3mmol) drying solvent xylene potassium carbonate in the reflux time 3 180 C senses a rotation velocity of the disk. 100 ml toluene cooled and room temperature after reaction adding woman star and aspiration filtered out, after silica gel column, then concentrated, acetic acid ethyl/methanol mixed solvent film by cleaning the solid compound (4.0g) of 53% are obtained.
According to the analysis of related databases, 2302-25-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Choe, Don Soo; Jo, Yun Hwan; (92 pag.)KR2015/80966; (2015); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem