In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Propylimidazole, other downstream synthetic routes, hurry up and to see.
Electric Literature of 50995-95-4, The chemical industry reduces the impact on the environment during synthesis 50995-95-4, name is 2-Propylimidazole, I believe this compound will play a more active role in future production and life.
Preparation of 2-chloro-6-(2-propylimidazol- 1 -vDpurine. Method 1: 2,6-Dichloropurine (0.38 g, 2 mmol) and 2-propylimidazole (1.32 g, 12 mmol) were dissolved in freshly distilled DMF (10 mL), and the mixture was stirred at 65 C for 20 h. Volatiles were evaporated in vacuo, and the residue was dissolved EPO in 0.1 N NaOH/H2O//CH2Cl2 (100 mL/50 mL). The organic phase was extracted with 0.1 N NaOHZH2O (3 x 50 mL). The combined aqueous phase was washed with CH2Cl2 (2 x 50 mL) and neutralized with CO2. The precipitated solid was filtered and washed (H2O) to give 2-chloro-6-(2-propylimidazol-l-yl)purine (0.38 g, 72%): mp 224.5-225 C; UV (MeOH) max 215, 288 nm (epsilon 25 800, 16 700), min 332, 241 nm (epsilon 2500, 4500); 1H NMR (500 MHz, DMSO-J6) delta 14.04 (br s, IH), 8.69 (s, IH), 8.43 (s, IH), 7.06 (s, IH,), 3.12 (t, J= 7.5 Hz, 2H), 1.72 (sext, J= 7.3 Hz, 2H), 0.95 (t, J= 7.3 Hz, 3H); 13C NMR ( 125 MHz, DMSO-^6) delta 157.3, 151.7, 150.2, 147.2, 146.6, 128.9, 122.5, 121.1, 32.4, 21.5, 14.5; HRMS m/z 262.0723 (M+ [Ci1H11ClN6] = 262.0734). Anal. Calcd for CnHnClN6: C, 50.29; H, 4.22; N, 31.99. Found: C, 50.02; H, 4.28; N, 31.64.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Propylimidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BRIGHAM YOUNG UNIVERSITY, TRANSFER TECHNOLOGY OFFICE; WO2006/138396; (2006); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem