Application of 20033-99-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20033-99-2, name is 2-(Hydroxymethyl)-5-methoxybenzimidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Example 34: Synthesis of 2-chloromethyl-5-methoxy-lH-benzoimidazole 222[0265] 2-Chloromethyl-5-methoxy-l H-benzoimidazole 222 was synthesized in 1 step from (5- Methoxy-lH-benzoimidazol-2-yl)-methanol 221 as shown in Scheme 58.Scheme 58Step 1 – Preparation of2-chloromethyl-5-methoxy-lH-benzoimidazole (222): [0266] (5-Methoxy-lH-benzoimidazol-2-yl)-methanol (221, 0.5 g, 3 mmol) was combined with 30 mL dichloromethane. Thionyl chloride (0.51 mL, 7 mmol) was added and the reaction was stirred at room temperature for 2 hours. The reaction was concentrated. Ethyl acetate was added and washed with sodium bicarbonate saturated solution and brine. The organic portion was dried over anhydrous sodium sulfate, filtered through Celite and evaporated to dryness. The resulting desired compound was used without further purification. MS (ESI) : [M+lT] + == 197.2.
The synthetic route of 2-(Hydroxymethyl)-5-methoxybenzimidazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PLEXXIKON, INC.; WO2008/80001; (2008); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem