Some common heterocyclic compound, 37619-25-3, name is Methyl 1H-benzo[d]imidazole-4-carboxylate, molecular formula is C9H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 37619-25-3
Methyl 1H-benzimidazole-4-carboxylate (315 mg) was dissolved in conc. sulfuric acid (3 mL), and the solutionwas stirred on ice bath. A small amount of potassium nitrate (199 mg) was added portion-wise, the solution was stirredat room temperature for 4 hours. The reaction mixture was poured into ice, alkalified with 3N aqueous sodium hydroxidesolution under stirring on ice bath, and extracted with ethyl acetate. The ethyl acetate layer was washed sequentiallywith water and brine, dried over anhydrous magnesium sulfate. The titled compound (334 mg) was obtained as colorlesspowder after distilling off a solvent under reduced pressure.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 37619-25-3, its application will become more common.
Reference:
Patent; Nippon Shinyaku Co., Ltd.; OTSU, Hironori; EP2746265; (2015); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem