Research on new synthetic routes about 5-Bromo-1-methyl-1H-imidazole

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-1-methyl-1H-imidazole, other downstream synthetic routes, hurry up and to see.

1003-21-0, Adding a certain compound to certain chemical reactions, such as: 1003-21-0, name is 5-Bromo-1-methyl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1003-21-0.

5-Bromo-1-methyl-1H-imidazole (0.50mmol), Pd(PPh3)2Cl2 (0.025mmol, 5.0mol%), K2CO3 (1.0mmol, 2.0mol equivalent), DMF (2.0mL), distilled water (2.0mL) and the corresponding phenylboronic acid (0.60mmol), were added in a 10mL round bottom flask. The mixture was stirred at 90C for 24h. After completion of the reaction, the mixture was cooled down to room temperature and extracted 3 times with ethyl acetate. The combined ethyl acetate extract was dried using anhydrous MgSO4. The solvent was removed under reduced pressure and the product was purified by silica gel column chromatography using hexane-ethyl acetate (1:1) followed by 7% methanol in ethyl acetate as an eluent.2.2.1 13 5-(4-Methoxyphenyl)-1-methyl-1H-imidazole (1) (0007) Yellow solid; isolated yield (83%); 1H NMR (500MHz, CDCl3) delta (ppm): 7.48 (s, 1H, C-H- arom), 7.30 (d, 2H, J=8.8Hz, C-H arom), 7.03 (s, 1H, C-H-arom), 6.96 (d, 2H, J=8.5Hz, C-H arom), 3.84 (s, 3H, CH3), 3.62 (s, 3H, CH3). 13C NMR (125MHz, CDCl3) delta (ppm): 32.20, 55.20, 114.03, 122.06, 127.39, 129.54, 129.78, 133.07, 138.47, 159.28 (C- arom); IR (v, cm-1): 3084, 2947, 1899, 1720, 1611, 1552,1491, 1234, 1116, 1023; GC-MS m/z: 188 (M+1). Anal. Calc. for C11H12N2O (188): C, 70.19; H, 6.43; N, 14.88. Found: C, 70.35; H, 6.83; N, 14.80.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-1-methyl-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ibrahim, Mansur; Malik, Imran; Mansour, Waseem; Sharif, Muhammad; Fettouhi, Mohammed; El Ali, Bassam; Journal of Organometallic Chemistry; vol. 859; (2018); p. 44 – 51;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem