Adding a certain compound to certain chemical reactions, such as: 50790-93-7, name is 2-Butylimidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 50790-93-7, Formula: C7H12N2
Preparation of 6-(2-butylimidazol- 1 -vD-2-chloropurine. A solution of 9-(2,3,5-tri-0-acetyl-beta-D-ribofuranosyi)-2,6-dichloropurine(2.41 g, 5.4 mmol) and 2-butylimidazole (6.68 g, 54 mmol) in CH3CN (60 mL) was stirred at 65 C under N2 for 32 h (reaction complete, TLC). Volatiles were evaporated in vacuo, and the residue was chromatographed (MeOHZCH2Cl2, 1:90) to give crude 9-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-6-(2-butylimidazol-l-yl)-2- chloropurine (3.33 g, contaminated with 2-butylimidazole): 1H NMR (500 MHz,CDCl3) delta 8.56 (s, IH), 8.24 (s, IH), 7.10 (s, IH), 6.26 (d, J= 5.8 Hz, IH), 5.83 (t, J = 5.6 Hz, IH), 5.61 (t, J= 5.6 Hz, IH), 4.43-4.51 (m, 3H), 3.31 (t, J= 7.9 Hz, 2H), 2.18 (s, 3H), 2.16 (s, 3H), 2.11 (s, 3H), 1.81 (quint, J= 7.7 Hz, 2H), 1.50 (sext, J= 7.7 Hz, 2H), 0.98 (t, J= 7.3 Hz, 3H); HRMS m/z 535.1702 (MH+ [C23H28ClN6O7] = 535.1708).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Butylimidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BRIGHAM YOUNG UNIVERSITY, TRANSFER TECHNOLOGY OFFICE; WO2006/138396; (2006); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem