312-73-2, name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 312-73-2
2-Trifluoromethyl-1H-benzimidazole 2 (1.35 g, 10 mmol)Was added to a round bottom flask equipped with 15 mL of acetone,After stirring, an alkene (alkyne) propyl bromide (0.87 mL, 10 mmol)And K2CO3 (2.07 g, 15 mmol),Heating reflux,TCL detection,After the reaction is complete,Cooling cooling,The solid was removed by filtration,The solid was washed with dichloromethane,The acetone solution was concentrated and mixed with the dichloromethane solution,Washed with H2O (15 mL x 3),The organic phase was dried over anhydrous MgSO4,Filtered and concentrated to get crude,To obtain 2.06 g of 1-propargyl-2-trifluoromethyl-1H-benzimidazole (3)Yield 91.96%.
Statistics shows that 312-73-2 is playing an increasingly important role. we look forward to future research findings about 2-(Trifluoromethyl)-1H-benzo[d]imidazole.
Reference:
Patent; Zhejiang University of Technology; Wang Yuguang; He Rongjun; Dong Huichan; Zhu Bingchun; (14 pag.)CN104496975; (2017); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem