These common heterocyclic compound, 914306-50-6, name is 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 914306-50-6
1-(2,6-diisopropylphenyl)-2-phenyl-1H-imidazole (2) (14.77 g, 48.5 mmol) was dissolved in DMF (200 ml) and NB S (9.50 g, 53.4 mmol) was added and the mixture was stirred at room temperature for 48 hours. More NBS (8.63 g, 48.5 mmol) was added and the reaction was stirred in a 70 C. oil bath for another 24 hours. Solvents were removed by kugelrohr and the residue was partitioned between EtOAc and water, filtering through a frit to remove black insoluble materials. The aqueous layer was extracted twice more with EtOAc, the organics were washed with water and brine, dried and purified by column chromatography to yield 3 as a colorless solid, 18.27 (81%).
The synthetic route of 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Universal Display Corporation; Szigethy, Geza; (140 pag.)US2018/319830; (2018); A1;,
Imidazole – Wikipedia,
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