Related Products of 115576-91-5, These common heterocyclic compound, 115576-91-5, name is (1-Methyl-1H-benzo[d]imidazol-5-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 11C : [1-METHYLBENZIMIDAZOLE-5-CARBOXALDEHYDE] A solution of 5-hydroxymethyl-1-methylbenzimidazole (0.8 g, 4 mmol) in acetone (40 [ML)] was treated with [MN02] (4 g) and the mixture was stirred for 3 days. The solid was filtered off and the solvent removed under reduced pressure to give 0.63 g of product. [COHGN2O] Mass (calculated): [160]; (found): [M+H+] = 161. NMR (400 [MHZ, DMSO-D6)] : 3.95 (3H, s, NCH3) ; 7.8 [(1H,] d, J = 8 Hz, aryl-H); 7.9 [(1H,] dd, [J =] 1 and 8 Hz, aryl-H); 8.3 [(1H,] d, J= 1 Hz, aryl-H); 8.45 [(1H,] s, imidazole-H); 10.1 [(1H,] s, CHO).
The synthetic route of 115576-91-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMGEN, INC.; WO2003/99814; (2003); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem