Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20033-99-2, name is 2-(Hydroxymethyl)-5-methoxybenzimidazole, A new synthetic method of this compound is introduced below., Quality Control of 2-(Hydroxymethyl)-5-methoxybenzimidazole
A suspension of (5-Methoxy-1H-benzimidazol-2-yl)methanol (preparation 1) (638 mg, 3.58 mmol) in 1N aqueous sodium hydroxide (0.95 ml) and water (40 ml) was heated to reflux and a solution of potassium permanganate (848 mg, 5.36 mmol) in water was added drop wise over a period of 30 minutes. The reaction mixture was refluxed for a further hour and then cooled to room temperature. The reaction mixture was acidified to pH4 by addition of acetic acid and the resulting solid filtered and dried in vacuo to give the title compound as a pale yellow solid (332 mg).
The synthetic route of 20033-99-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Lane, Charlotte Alice Louise; Price, David Anthony; US2006/111416; (2006); A1;,
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