Synthetic Route of 39811-07-9, These common heterocyclic compound, 39811-07-9, name is (5-Fluoro-1H-benzo[d]imidazol-2-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
N-Methyl-2-methanol-5-flourobenzimidazole 51 was prepared according to using the procedure by Harisha et al. [28]. A solution of (5-fluoro-1H-benzimidazole-2-yl) methanol 29 (0.42 g, 2.5 mmol), and sodium hydroxide (0.1 g, 2.5 mmol) were stirred in dry acetone (8 mL) for 30 min. Then, iodomethane (0.35 g, 2.5 mmol) was added and the mixture was stirred for 24 h. The reaction mixture was concentrated to a quarter and then poured into ice-cold water. The solid was filtered and washed with 50% HCl to neutralize the excess potassium carbonate. The solid was washed with cold water (25 mL) and aqueous ethanol. The desired product 51 was dried and recrystallized from ethanol to give pale cream crystals Yield 53%.
The synthetic route of 39811-07-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Alasmary, Fatmah A.S.; Snelling, Anna M.; Zain, Mohammed E.; Alafeefy, Ahmed M.; Awaad, Amani S.; Karodia, Nazira; Molecules; vol. 20; 8; (2015); p. 15206 – 15223;,
Imidazole – Wikipedia,
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