Related Products of 17289-26-8, These common heterocyclic compound, 17289-26-8, name is 1-Methyl-1H-imidazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1: Synthesis of 4-ethynyl-1-methyl-1H-imidazole A solution of l-methyl-1H-imidazole-4-carbaldehyde (2 g, 1 eq) in MeOH (180 ml) was cooled at 0 C. K2CO3(5.02 g, 2 eq) and dimethyl (1-diazo-2-oxopropyl)phosphonate (7.7 g, 2.2 eq) was added. The mixture was stirred for 4 hr at 0 C., and extracted with dichloromethane and water. The organic layer was washed with sat. aq. NH4Cl, dried over anhydrous MgSO4 and concentrated in vacuo. The residue was purified with column chromatography to prepare the title compound (1.2 g, 62%). 1H NMR (600 MHz, CDCl3-d1); delta7.60 (s, 1H), 7.32 (m, 1H), 3.37 (s, 3H), 3.48 (s, 1H). MS (ESI, m/z): 107.1 [M+H]+.
Statistics shows that 1-Methyl-1H-imidazole-4-carbaldehyde is playing an increasingly important role. we look forward to future research findings about 17289-26-8.