Electric Literature of 1544-75-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1544-75-8 as follows.
[00312] lodomethane (0.82 mL, 13.15 mmol) was added to a mixture of 5-fluoro-1,3-dihydro-2H-benzimidazol-2-one (500. mg, 3.29 mmol) and potassium carbonate (1.81 g, 13.15mmol) in DMF (25 mL), and the reaction mixture stirred at ambient temperature for 16 h. DCM(30 mL) and water (60 mL) were added and the mixture stirred for 5 min. The DCM layer wasisolated by passing through a hydrophobic frit and the aqueous washed with DCM (2 x 50mL). The combined DCM extracts were concentrated under reduced pressure to yield 5-fluoro-1,3-dimethyl-benzimidazol-2-one (556 mg, 2.99 mmol, 91%).[00313] 1H NMR (300MHz, CDCI3) 5 = 6.91 – 6.71 (m, 3H), 3.42 (s, 3H), 3.41 (s, 3H)
According to the analysis of related databases, 1544-75-8, the application of this compound in the production field has become more and more popular.