Application of 96797-15-8, These common heterocyclic compound, 96797-15-8, name is 4-Iodo-1-trityl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[275] To an ice-salt bath cooling solution of 4-iodo-1-trityl-1H-imidazole (2.5 g, 5.7 mmol) in dichloromethane (DCM) (30 mL) was added ethylmagnesium bromide (2.5 mL, 7.5 mmol, 3.0 M solution in diethyl ether) slowly. The resulted mixture was stirred at roomtemperature for lh, then added chlorotributyltin (2.6 g, 8.0 mmol). The resulted mixture was stirred at room temperature for 2h, then added saturated ammonium chloride solution (50 mL), the mixture was extracted with dichloromethane (100 mLx2). The combined organic phase was washed with brine (25 mL), dried over sodium sulfate, filtered and concentrated. The residue was recrystallization with a mixed solvent (petroleum ether: ethyl acetate= 6:1) toafford 4-(tributylstannyl)-1-trityl-1H-imidazole (2.6 g, yield: 76%) as a white solid.[276] m/z: [M+H] 601
Statistics shows that 4-Iodo-1-trityl-1H-imidazole is playing an increasingly important role. we look forward to future research findings about 96797-15-8.