Electric Literature of 1402838-08-7,Some common heterocyclic compound, 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, molecular formula is C29H22N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-(1-trityl-1H-imidazol-4-yl)benzaldehyde (0105-1) (200 mg, 0.483 mmol, 1.0 equiv),Compound (2-(Diphenyl[b,d]furan-2-yl)-2-oxoethyl)phosphoric acid dimethyl ester (0604-96) (170 mg, 0.53 mmol, 1.1 eq) andCesium carbonate (315 mg, 0.966 mmol, 2.0 equiv)Mixed in isopropyl alcohol (30 ml),The reaction was stirred at room temperature overnight. After the reaction is over, add water andSolids precipitated, filtered and the cake was dried to give the product 1-(diphenyl[b,d]furan-2-yl)-3-(2-(1-trityl-1H-)Imidazol-4-yl)phenyl)prop-2-en-1-one (300 mg, crude).
The synthetic route of 1402838-08-7 has been constantly updated, and we look forward to future research findings.