Electric Literature of 28890-99-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
In a 250ml three-necked bottle, Under the protection of nitrogen, Add 0.01mol of raw material A-1, 0.012mol of raw material B-1, Stir and mix 150ml of toluene, Then add 0.03mol sodium tert-butoxide, 5×10-5molPd2(dba)3, 5×10-5mol tri-tert-butylphosphine, heated to 105C, refluxed for 24 hours, Sampling point plate, showing no bromide remaining, The reaction is complete; naturally cool to room temperature, filter, The filtrate was subjected to vacuum rotary evaporation (-0.09MPa, 85C), and passed through a neutral silica gel column to obtain the target product. The HPLC purity was 98.4%, and the yield was 89.2%; elemental analysis structure (molecular formula C25H16BrN3):
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, other downstream synthetic routes, hurry up and to see.