Extracurricular laboratory: Synthetic route of Imidazole-2-carboxaldehyde

The synthetic route of 10111-08-7 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 10111-08-7, These common heterocyclic compound, 10111-08-7, name is Imidazole-2-carboxaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In DMF (15 ml), 2-imidazole carboxaldehyde (500 mg) was dissolved. Then, the solution was added with iodoethane (1.25 ml) and sodium hydride (208 mg), followed by stirring at room temperature for 5 days. After completion of the reaction, the solvent was distilled off and the residue was then added with chloroform, followed by washing with water and saturated saline solution. The resultant was dried with anhydrous sodium sulfate, and the solvent was then distilled off. The residue was purified through silica gel column chromatography (chloroform/methanol), thereby obtaining the subject compound (280 mg) as a yellow oily substance. 1H-NMR(500MHz,DMSO-d6):delta=1.44(3H,t,J=7.3Hz),4.44 (2H,q,J=7.3Hz),7.18(1H,s),7.29(1 H,s),9.82(1H,s).

The synthetic route of 10111-08-7 has been constantly updated, and we look forward to future research findings.