Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 41716-18-1, name is 1-Methyl-1H-imidazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., name: 1-Methyl-1H-imidazole-4-carboxylic acid
A mixture of the amine 32 (500 mg, 1.5 mmol), N-methyl-imidazol-4-yl carboxylic acid ( 212 mg, 1.7 mmol), HOBT (218 mg, 1.6 mmol), DCC (353 mg, 1.8 mmol) and triethyl amine (0.64 ml, 4.6 mmol) in dry dichloromethane (15 ml) was stirred at room temperature for 5 days. The reaction mixture was poured into ethyl acetate and washed with 1 N NaOH (1 X), brine (1 X), dried and concentrated. The crude product was purified by chromatography using the ISCO purification system to provide the desired product 33 (590 mg) as a solid. 1H NMR (400 MHz, CHLOROFORM-d) deltappm 1.25 (s, 2 H) 1.43 (s, 8 H) 1.58 (s, 5 H) 1.85 (s, 2 H) 2.01 (s, 1 H) 2.14 (s, 1 H) 2.50 (s, 3 H) 2.58 (s, 1 H) 2.74 (s, 1 H) 3.69 (s, 5 H) 3.88 (s, 1 H) 5.18 (s, 1 H) 7.25 (S, 2 H) 7.40 (s, 2 H); LCMS (m/z) 435.0 (M+H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 41716-18-1.