In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 716-79-0 as follows. Application In Synthesis of 2-Phenyl-1H-benzo[d]imidazole
General procedure: To a stirred solution of 2-phenyl-1H-benzo[d]imidazole 7a (50 mg, 0.26 mmol) and NaH (7 mg, 0.31 mmol) in DMF (0.5 mL) was added methyl bromoacetate (29 muL, 0.31 mmol) dropwise. After stirring at room temperature for 16 h, the reaction mixture was extracted with EtOAc (3 ~ 20 mL) and washed with H2O (~ 20 mL). The organic layer was dried over anhydrous MgSO4, and concentrated in vacuo. The residue was purified by column chromatography (SiO2, n-hexane/EtOAc 2/1) to yield the title product 8a (35 mg, 50percent). 1H NMR (300 MHz, CDCl3) delta ppm 7.87 (m, 1H) 7.72 (m, 2H) 7.54 (m, 3H) 7.35 (m, 3H) 4.93 (s, 2H) 3.82 (s, 3H); LC/MS (ESI+, MeCN/H2O): m/z: calcd for C15H13N2O2: 253.09 [M + H]+; found: 253.1.
According to the analysis of related databases, 716-79-0, the application of this compound in the production field has become more and more popular.