These common heterocyclic compound, 68282-53-1, name is 5-Methyl-1H-imidazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 68282-53-1
COMPOUND 12.1. 26: N,N-DIETHYL-4-{7-HYDROXY-6-METHOXY-2-[(5- METHYL-1H-IMIDAZOL-4-YL)METHYL]-1,2,3, 4- TETRAHYDROISOOUINOLIN-1-YL} BENZAMIDE; To a solution of INTERMEDIATE 5.1. 12 (56 mg, o. 158 mmol) in anhydrous dichloromethane (3.5 mL) was added 4-methyl-lH-imidazole-5-carboxaldehyde (2. 5eq, 43 mg, 0.395 mmol) and followed by sodium triacetoxyborohydride (4eq, 134 mg, 0.623 mmol). The reaction mixture was stirred at room temperature for 20hr then quenched with saturated aqueous sodium bicarbonate and extracted with ethyl acetate (2 x 20 mL), dried over MgS04. Solvent was removed and the residue purified by preparative column chromatography to give 60 mg (0.1339 mmol, 84%) of COMPOUND 12.1. 26 as a white solid. 1H NMR (500 MHz, CDC13) : 8 1.15 (br s, 3H), 1.30 (br s, 3H), 2.08 (s, 3H), 2.61 (m, 1H), 2.78 (m, 1H), 2.98 (m, 1H), 3.18 (m, 1H), 3. 36 (br s, 2H), 3.40 (d, J 10 Hz, 1H), 3. 58 (br s, 2H), 3. 68 (d, J 10 Hz, 1H), 3. 80 (s, 3H), 4.58 (s, 1H), 6.15 (s, 1H), 6.70 (s, 1H), 7.35 (d, J 8 Hz, 2H), 7.40 (d, J 8 Hz, 2H), 7.75 (s, 1H). 13C NMR (125 MHz, CDC13) : 5 9. 10, 12.00, 13.05, 27.75, 39.80, 43.80, 49.05, 55.25, 68.02, 111.15, 114.97, 125. 66,126. 13,127. 44,128. 00,129. 42, 129. 89, 133.19, 135.99, 144.60, 146.00, 146.82, 172.50. (+) LRESIMS m/z 449 (M+H)+.
The synthetic route of 5-Methyl-1H-imidazole-4-carbaldehyde has been constantly updated, and we look forward to future research findings.