Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 139481-44-0, name is Methyl 1-((2′-cyano-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate, A new synthetic method of this compound is introduced below., Formula: C25H21N3O3
Starting material (Compound 2A) 20 g, placed in a reaction flask, adding ethanol 200ml, 5 g of triethylamine, 37 g of 50% aqueous hydroxylamine solution, the reaction 24h, cooling crystallization to give a white solid 13.6 g (63.0%). At the end of the reaction the reaction mixture by HPLC lactam impurity was mainly (Compound. 6A): the product was 7.15%: 92.84% (i.e. a ratio of an impurity with the product: 12.9),
The synthetic route of 139481-44-0 has been constantly updated, and we look forward to future research findings.