Continuously updated synthesis method about 4-Methyl-1H-imidazole

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 822-36-6, name is 4-Methyl-1H-imidazole, A new synthetic method of this compound is introduced below., Product Details of 822-36-6

4-Methylimidazole (249 mg, 3.03 mmol), 4-fluoro-3-methoxybenzonitrile (417 mg, 2.76 mmol), and cesium carbonate (1.89 g, 5.80 mmol) were placed in a reaction vessel in a nitrogen gas atmosphere, N,N-dimethylformamide (5.0 mL) was added to the vessel and the resultant mixture was stirred at room temperature for 96 hours. To the reaction mixture were successively added water (2 mL) and ethyl acetate (6 mL) to perform an extraction, and the aqueous layer was separated and then, the organic layer was washed with water (5 mL). To the organic layer were added ethyl acetate (5 mL) and water (5 mL) to perform an extraction, and the aqueous layer was separated and then, the organic layer was washed with water (5 mL) and concentrated under a reduced pressure to obtain 499 mg of a crude product. To the crude product was added tert-butyl methyl ether (2.5 mL) to obtain a suspension, and the solids collected by filtration of the suspension were washed with tert-butyl methyl ether/heptane (2.5 ml; 1 :3) three times to obtain 431 mg of a crude product. To the obtained crude product was added tert-butyl methyl ether (4.3 mL) in a nitrogen gas atmosphere, and the resultant mixture was stirred at 50C for 30 minutes and then naturally cooled to room temperature, and the solids collected by filtration were washed with tert-butyl methyl ether/heptane (2.1 mL; 1 :3) twice and dried under a reduced pressure to obtain 310 mg of a title compound. Yield: 53%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.