Synthetic Route of 53981-69-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53981-69-4, name is 1-(1H-Imidazol-2-yl)ethanone belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
alpha-Mangostin (1, 205 mg, 0.5 mmol) was dissolved in dichloromethane (10 mL) and acetylimidazole (55 mg, 0.5 mmol) was added at room temperature. After 6 hours, additional acetylimidazole (55 mg, 0.5 mmol) was added and the reaction was allowed to proceed overnight. The mixture was then diluted with ethyl acetate (15 mL) and washed in succession with 1M HCl (2 × 10 mL), saturated sodium hydrogen carbonate (2 × 10 mL) and saturated sodium chloride (2 × 10 mL). The organic layer was dried (sodium sulfate) and the solvent was evaporated under reduced pressure to give a yellow, oily solid (210 mg). Flash-column chromatography of the residue (silica gel, ethyl acetate/hexane 15 : 85) afforded three fractions: 3,6-O-diacetyl–mangostin (4, yellow solid, 20 mg, 8% yield); 3-O-acetyl–mangostin (6, yellow solid, 100 mg, 44% yield); unreacted -mangostin (1, yellow solid, 40 mg, 20 %).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(1H-Imidazol-2-yl)ethanone, other downstream synthetic routes, hurry up and to see.