Application of 1849-01-0,Some common heterocyclic compound, 1849-01-0, name is 1-Methyl-1H-benzo[d]imidazol-2(3H)-one, molecular formula is C8H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Take 10 ml sealed,Weigh 50 mg 1f,139 mg 2b,154 mg of cesium fluoride,Add 2 ml of acetonitrile, pump for nitrogen, 90 reaction 12h.The solvent was then removed by distillation under reduced pressure to give petroleum ether and ethyl acetate as eluant,The residue was purified by silica gel column chromatography to give 3 fb as a white solid in 53% yield.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-benzo[d]imidazol-2(3H)-one, its application will become more common.