Synthetic Route of 7098-07-9, A common heterocyclic compound, 7098-07-9, name is 1-Ethyl-1H-imidazole, molecular formula is C5H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 750 mL three-necked flask, 1-ethyl-1H-imidazole (3 g, 3.13 ml, 31.2 mmol, Eq: 1.00) was combined with DCM (140 ml) to give a colorless solution. 1,3-Dibromo-5,5-dimethylimidazolidine-2,4-dione (4.55 g, 15.9 mmol, Eq: 0.51), dissolved in DCM (140 ml), was added dropwise at 0° C. during 20 min. to give a dark green solution. The reaction mixture was stirred at 0° C. for another 2 h. Work up: The reaction mixture was poured into 125 mL sat Na2SO3, extracted with DCM (2*100 mL) and washed with H2O/brine (20 ml). The organic layers were combined, washed with brine, dried over Na2SO4, and concentrated i. V. Purification: The crude product was purified by flash chromatography (silica gel, 400 g, 5percent MeOH in DCM) go give 1.66 g of pure title compound as yellow liquid. MS (ESI): 175.0, 177.0 [M+H]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.