Application of 4856-97-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4856-97-7 as follows.
Into a 100 ml three neck RB flask containing Ar(g) was placed DMF (40 ml), followed by (lH-benzo[d]imidazol-2-yl)methanol (2.20 g, 14.9 mmol), thus forming a pale orange solution. This was cooled to 0 °C and 60percent sodium hydride (0.772 g, 19.3 mmol) was added in one portion. After stirring for 10 min under Ar(g) at 0 °C, 4-bromobutanenitrile (2.64 g, 17.8 mmol) was added in one portion. The reaction was allowed to warm to rt and left to proceed for 18 h. The reaction mixture was diluted with DCM and then poured onto a brine solution. The organic layer was separated and the aqueous phase was extracted three times with DCM. The combined organic fractions were dried over anhydrous sodium sulfate and then concentrated in vacuo. Purification by column chromatography (100percent DCM to 3percent MeOH/DCM) afforded the desired product as a viscous oil which solidified to a white solid over a period of hours (2.99 g, 13.9 mmol, 94percent). 1H NMR (400 MHz, DMSO-d6) delta 7.60-7.53 (m, 2H), 7.26 – 7.19 (m, 1H), 7.19 – 7.13 (m, 1H), 5.65 (t, J = 5.8 Hz, 1H), 4.70 (d, J = 5.8 Hz, 2H), 4.39 – 4.25 (m, 2H), 2.56 (t, J = 7.3 Hz, 2H), 2.15 – 2.01 (m, 2H)
According to the analysis of related databases, 4856-97-7, the application of this compound in the production field has become more and more popular.