Synthetic Route of 4887-80-3,Some common heterocyclic compound, 4887-80-3, name is 5-Methoxy-1H-benzo[d]imidazole, molecular formula is C8H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
5-Methoxybenzimidazole (0.50 g, 3.37 mmol) was dissolved in acetonitrile (5 mL), potassium hydroxide (0.39 g, 6.95 mmol) was added, and the mixture was refluxed for 30 min. 2-(Bromomethyl)naphthalene (0.76 g, 3.44 mmol) was added, and the mixture was refluxed overnight.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Methoxy-1H-benzo[d]imidazole, its application will become more common.
Reference:
Article; Shelton, Kerri L.; DeBord, Michael A.; Wagers, Patrick O.; Southerland, Marie R.; Williams, Travis M.; Robishaw, Nikki K.; Shriver, Leah P.; Tessier, Claire A.; Panzner, Matthew J.; Youngs, Wiley J.; Bioorganic and Medicinal Chemistry; vol. 25; 1; (2017); p. 421 – 439;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem