28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 28890-99-5
d) Intermediate (E-3) (1.3 g, 7.0 mmol) and benzoimidazolo[1,2-a]benzimidazole (1.52 g, 7.3 mmol) were entered in N-methylpyrrolidone (20 mL). To the mixture was potassiumphosphate (3.12 g, 14.7 mmol) added, and the mixture was stirred at 180C for 40 h. After the reaction mixture was cooled at room temperature, 50 mL of water was poured into the reaction mixture to give a grey solid. The solid was collected by filtration, and washed with water and ethanol. The crude product was purified by column chromatography on silica gel eluting with CH2CI2 to yield 1.87 g (71%) of compound (B-i) as a white solid.1HNMR (300 MHz, CDCI3): 6 7.98-7.95 (m, 2H), 7.81-7.73 (m, 4H), 7.63 (dt, J = 0.8,8.3Hz, 1H), 7.45-7.35 (m, 4H), 730-7.26 (m, 1H), 7.12 (dt, J= 0.8, 8.0 Hz, 1H), 7.04 (td, J=0.9, 7.6 Hz, 1 H), 6.91 (dq, J = 0.6, 1.5, 7.9 Hz, 1 H)
The synthetic route of 28890-99-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; IDEMITSU KOSAN CO., LTD.; NISHIMAE, Yuichi; KOHLSTEDT, Julia; SCHAeFER, Thomas; NAGASHIMA, Hideaki; (114 pag.)WO2016/97983; (2016); A1;,
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