Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10597-52-1, name is 7-Nitro-1H-benzo[d]imidazole, A new synthetic method of this compound is introduced below., Recommanded Product: 7-Nitro-1H-benzo[d]imidazole
To a stirred suspension of benzimidazole 34 (4.11 g, 30.6 mmol) in 230 mL of CH3CN was added BSA (8.22 mL,39.8 mmol), and the solution was stirred for 10 min during which time the reaction mixture became homogenous. TAR (9.65 g, 39.8 mmol) was added followed by TMSOTf (5.88 mL, 38.8 mmol) and the reaction was heated to reflux for 3 h before being cooled to rt and diluted with 200 mL of EtOAc. The organic layer was washed with 200mL of satd. NaHCO3 and 200 mL of brine. The organic layer was then dried (Na2SO4), filtered, and concentrated in vacuo to afford a yellow oil. The oil was purified by flash chromatography (0-20% MeOH/DCM) to afford the triacetate 35
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Brockway, Anthony J.; Volkov, Oleg A.; Cosner, Casey C.; MacMillan, Karen S.; Wring, Stephen A.; Richardson, Thomas E.; Peel, Michael; Phillips, Margaret A.; De Brabander, Jef K.; Bioorganic and Medicinal Chemistry; vol. 25; 20; (2017); p. 5433 – 5440;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem