Reference of 98873-55-3,Some common heterocyclic compound, 98873-55-3, name is 2-(1H-Imidazol-1-yl)acetonitrile, molecular formula is C5H5N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of 2-(lH-imidazol-l-yl)acetonitrile (400 mg, 3.73 mmol) in dimethylsulfoxide (5 mL), potassium hydroxide (461 mg, 8.22 mmol) was added at 0 C and stirred for 30 min at 25 C. To this reaction mixture, carbon disulfide (0.29 mL, 4.85 mmol) was added and stirred for another 15 min. 5,6-Dichloropyrazine-2,3-dicarbonitrile (743 mg, 3.73 mmol) was added portion- wise to the reaction mixture and allowed to stir for 2 h at 25 C. After completion of the reaction, water was added to the reaction mixture and the product was extracted twice with ethyl acetate (50 mL). Ethyl acetate layer was washed with brine (50 mL), dried over anhydrous sodium sulphate, filtered and evaporated under reduced pressure to obtain a crude product. The crude product was then purified by column chromatography on silica gel (eluent-hexane to 40% ethyl acetate in hexane) to obtain 2-(cyano(lH-imidazol-l-yl)methylene)-[l,3]dithiolo[4,5-b]pyrazine-5,6-dicarbonitrile (350 mg, 1.31 mmol, 30% yield).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(1H-Imidazol-1-yl)acetonitrile, its application will become more common.
Reference:
Patent; PI INDUSTRIES LTD.; SAXENA, Rohit; PUJARI, Sandip Appaji; THOK, Sambhaji Shivnath; DEBNATH, Sankha; RAJU, Jella Rama; MISHRA, Rupesh Kumar; GARG, Ruchi; AUTKAR, Santosh Shridhar; VENKATESHA, Hagalavadi M; KLAUSENER, Alexander G.M.; (110 pag.)WO2019/150311; (2019); A1;,
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