Electric Literature of 147403-65-4,Some common heterocyclic compound, 147403-65-4, name is Methyl 2-ethoxy-1-((2′-(N-hydroxycarbamimidoyl)-[1,1′-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate, molecular formula is C25H24N4O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound (3A) 9.5 g, placed in a reaction flask was added dichloromethane 100ml, 5ml of triethylamine was added dropwise 2.5 g of methyl chloroformate, the reaction at room temperature for 2 hours.Water was added to 60ml, stirring layers were separated dichloromethane layer was separated, and the aqueous layer extracted with dichloromethane, dichloromethane layers were combined, dried over anhydrous sodium sulfate, filtered, and concentrated to give the crude product was purified by solid 8.2, yield 79 %.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-ethoxy-1-((2′-(N-hydroxycarbamimidoyl)-[1,1′-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate, its application will become more common.
Reference:
Patent; Shanghai Institute of pharmaceutical industry; Wang, Xiaomei; Sui, Qiang; Tang, Chao; Ouyang, Qunxiang; Shi, Huilin; Liu, Shuai; (18 pag.)CN103664920; (2016); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem