Reference of 614-97-1,Some common heterocyclic compound, 614-97-1, name is 5-Methyl-1H-benzo[d]imidazole, molecular formula is C8H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step B – Synthesis of Compounds DD3 and DD4; To a solution of compound DD2 (24.5 mmol) in CH3CN (65 mL) was added di- tertbutyl dicarbonate (5.89 g, 27.0 mmol), triethylamine (3.76 mL, 27.0 mmol) and 4- dimethylamino pyridine (300 mg, 2.45 mmol) and the resulting reaction was heated to 800C and allowed to stir at this temperature for 1.5 hours. The reaction mixture was cooled to room temperature, concentrated in vacuo, and the residue obtained was purified using flash column chromatography (silica gel, EtOAc/Hexanes 5-20%) to provide a mixture of isomeric compounds DD3 and DD4 (5.38 g, 94.3% yield over steps A and B).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Methyl-1H-benzo[d]imidazole, its application will become more common.
Reference:
Patent; SCHERING CORPORATION; WO2008/82488; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem