Application of 1402838-08-7,Some common heterocyclic compound, 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, molecular formula is C29H22N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of tert-butyl 5-oxo-2-azaspiro[3.4]octane-2-carboxylate (2 g, 8.89 minol), 2-[ 1 -(triphenylmethyl)- I. H-iniidazol-4-y1]benzaldehyde (5.53 g, 13.34 mmol) and Ca(OH)2 (1.64g. 22.13 mniol) in EtOH (250 mL) was stirred for 6 hat 80C. The solids were filtered out. The solids were filtered out. The solvent was concentrated under vacuum. The residue was purified by silica gel column eluting with EtOAc /PE (1:2). This resulted in 5.24 g (95%) of tert-butyl (6E)-5-oxo-6-([2-[ 1 -(triphenyl.methyl)-1 H-imidazoi-4-yljphenyljmethylidene)-2-azaspiro[3.4]octane-2-carboxylate as a light yellow solid. LCMS (ESI)mJz = 622.8 [.M+Hr.
The synthetic route of 1402838-08-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GENENTECH, INC.; PEI, Zhonghua; PASTOR, Richard; GAZZARD, Lewis; PARR, Brendan; LIU, Wendy; MENDONCA, Rohan; WU, Guosheng; YUEN, Po-Wai; (183 pag.)WO2019/5559; (2019); A1;,
Imidazole – Wikipedia,
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