Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 32692-19-6, name is 5-Nitroindoline, A new synthetic method of this compound is introduced below., name: 5-Nitroindoline
Example V; 5-nitro-1 -pyrimidin-2-yl-2,3-dihydro-1 H-indole300 mg 5-nitro-2,3-dihydro-1 H-indole are dissolved in 4 ml N-methyl- pyrrolidine. 80 mg NaH (60 % suspension in mineral oil) are added and the mixture is stirred for 15 minutes at ambient temperature. Then 380 mg of 2- bromopyrimidine are added and the mixture is then heated to 600C for 3 hours. It is then diluted with diethyl ether and washed with dilute citric acid solution and saturated sodium chloride solution. After drying with magnesium sulphate the solvents are eliminated in vacuo. Yield: 410 mg (95 % of theory) Rf value: 0.61 (silica gel: ethyl acetate/petroleum ether 1 :1 )
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2009/16118; (2009); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem